99% Pharmaceutical Aldactone for Anti-Androgen

Quick Detail:

Product Name: Aldactone 
CAS:52-01-7
MF:C24H32O4S
MW:416.57
EINECS:200-133-6
Product Categories:Active Pharmaceutical Ingredients;Biochemistry;Steroids;Steroids (Others);Intermediates & Fine Chemicals;Pharmaceuticals;API's;ALDACTONE
Mol File: 52-01-7.mol

Description:

Aldactone is a kind of weak potassium-sparing diuretics, and is fine white or white-like crystalline powder with slightly bitter taste. It is odorless or with slight mercaptan odor. It is highly soluble in chloroform but insoluble in water and soluble in ethanol, and easily soluble in benzene or ethyl acetate. It has a similar chemical structure as aldosterone and can compete with aldosterone for the aldosterone receptors in the cytoplasm of the distal convoluted tubule and collecting tube duct cells, affecting the binding of the aldosterone to its receptor, thus preventing the synthesis of aldosterone-induced protein and further inhibiting the exchange between K+ and Na+ with reduced potassium excretion and plays potassium-sparing diuretic effect. The strength of the diuretic effect of Aldactone is related to the in vivo secretion of aldosterone with increased secretion also causing stronger effect while lower secretion causing weaker effects. It has no diuretic effect on patients without aldosterone secretion. Because the drug only acts on the distal convoluted tubule and collecting duct while having no effect on the other segments of tubular, it only has a weak diuretic effect with slow onset but long duration time. It is mainly used for treating refractory edema accompanied with higher amount of aldosterone such as cirrhosis, congestive heart failure, and nephrotic syndrome with excellent efficacy in treating the patients with hyperaldosteronism caused by the lack of sodium in the congestive heart failure. Single drug administration usually only give a poor diuretic and therefore, it is often used in combination with hydrochlorothiazide or dihydrochlorothiazide for enhancing the effect. In addition, it can also be applied to the treatment of primary hyperaldosteronism and hypertension. Patients of hyperkalemia or renal failure should be disabled. 

This product has a rapid and irregular absorption rate after oral administration with the absorption rate being relate to the spironolactone particle size. According to general process, the bioavailability is only about 5% while the absorption rate can reach 90% when made into fine particles with the time for the plasma concentration reaching the peak with approximately 3 hours. It has rapid metabolism rate in vivo with its major metabolites being canrenone which can exert the pharmacological activity and other metabolites also being gradually converted into canrenone. The serum metabolites level will reach peak at 2 to 4 hours after single dose of oral administration. The concentration of metabolites will decrease rapidly within 12 hours with slow decline in 12 to 96 hours. After oral administration of multiple doses, the half life of the canrenone metabolite was 13 to 24 hours. The half-life of spirono*lactone is only about 10 minutes. The plasma protein binding rate of canrenone is about 98%. Its metabolites can be secreted through the bile and urine. The canrenone metabolism includes enterohepatic circulation. It can penetrate through the placental barrier and enter into breast milk. It also has effects of inhibiting estrogen and androgen synthesis.

Uses:  
 
It can be used as a kind of inefficient diuretic drugs. 
It is a synthetic 17-lactone steroid which is a kind of renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension and hypokalemia. 
The active metabolite of lactone; It can be used for the Inhibition of aldosterone biosynthesis. It can also be used as the blocker of the Quabain effect.

Our Delivery:







FAQ:

1)Location & Working Hours
We are an International source locate in China.
I will answer emails from Monday to Saturday, 8:30 am to 18:00 pm (GMT+8)

2)How long does it takes to get back a response from you?
You should receive a response in less than 24 hours.

3)How do I make an order?
When you choosed the products, please email me, and I will quote for you, if you are satisfied with it, then pay for it, the parcle will be sent for you as soon as possible.

4)How to track my order?
 After I ship your order and have the tracking number, you will receive an email notification. All tracking numbers I provide can be tracked at http://www.17track.net/en. Or you can ask me for helping you track it too.

5)How long does the whole process take, from making an order till receiving the package?
The package will be prepared within 1 working day after payment received and be sent out within 72 hours. 
The delivery time depends on the shipping situation and customs. 
The shipping time will not more than 15 working days at most.

6)How about  the shipping cost?
The shipping cost is for the whole order. No matter how many different items and quantity in one orders. The shipping cost will be charged only once.

7)Is there a minimum order?
For raw powder: MOQ is 10g
For oil liquid: MOQ is 50ml
For peptide vial: MOQ is 10 vials

8)Reship Policy
To U.S. We reship for free twice if your package gets seized. 
To other countries we reship for free once if your package gets seized. 
If you choose not to reship or the resent package failed to go through again, no refund will be made.

9)Payment Ways
We accept Bank Transfer(T/T ), Western Union, Moneygram, Bitcoin.
*** The Bitboin is a little special for us, our Bitcoin account is always changing, once I gave you the account number, please pay for it at once.  

10)Refund policy
Our company has a 2 reship policy all foreign countries in case of a seizure.
**We are not responsible if you throw away your products because you cannot find them in our disguised package. If you cannot find your products please email me and I will tell you where to find them.


More Hot Sale Products:
  Quick Detail:

Product Name: Aldactone 
CAS:52-01-7
MF:C24H32O4S
MW:416.57
EINECS:200-133-6
Product Categories:Active Pharmaceutical Ingredients;Biochemistry;Steroids;Steroids (Others);Intermediates & Fine Chemicals;Pharmaceuticals;API's;ALDACTONE
Mol File: 52-01-7.mol

Description:

Aldactone is a kind of weak potassium-sparing diuretics, and is fine white or white-like crystalline powder with slightly bitter taste. It is odorless or with slight mercaptan odor. It is highly soluble in chloroform but insoluble in water and soluble in ethanol, and easily soluble in benzene or ethyl acetate. It has a similar chemical structure as aldosterone and can compete with aldosterone for the aldosterone receptors in the cytoplasm of the distal convoluted tubule and collecting tube duct cells, affecting the binding of the aldosterone to its receptor, thus preventing the synthesis of aldosterone-induced protein and further inhibiting the exchange between K+ and Na+ with reduced potassium excretion and plays potassium-sparing diuretic effect. The strength of the diuretic effect of Aldactone is related to the in vivo secretion of aldosterone with increased secretion also causing stronger effect while lower secretion causing weaker effects. It has no diuretic effect on patients without aldosterone secretion. Because the drug only acts on the distal convoluted tubule and collecting duct while having no effect on the other segments of tubular, it only has a weak diuretic effect with slow onset but long duration time. It is mainly used for treating refractory edema accompanied with higher amount of aldosterone such as cirrhosis, congestive heart failure, and nephrotic syndrome with excellent efficacy in treating the patients with hyperaldosteronism caused by the lack of sodium in the congestive heart failure. Single drug administration usually only give a poor diuretic and therefore, it is often used in combination with hydrochlorothiazide or dihydrochlorothiazide for enhancing the effect. In addition, it can also be applied to the treatment of primary hyperaldosteronism and hypertension. Patients of hyperkalemia or renal failure should be disabled. 

This product has a rapid and irregular absorption rate after oral administration with the absorption rate being relate to the spironolactone particle size. According to general process, the bioavailability is only about 5% while the absorption rate can reach 90% when made into fine particles with the time for the plasma concentration reaching the peak with approximately 3 hours. It has rapid metabolism rate in vivo with its major metabolites being canrenone which can exert the pharmacological activity and other metabolites also being gradually converted into canrenone. The serum metabolites level will reach peak at 2 to 4 hours after single dose of oral administration. The concentration of metabolites will decrease rapidly within 12 hours with slow decline in 12 to 96 hours. After oral administration of multiple doses, the half life of the canrenone metabolite was 13 to 24 hours. The half-life of spirono*lactone is only about 10 minutes. The plasma protein binding rate of canrenone is about 98%. Its metabolites can be secreted through the bile and urine. The canrenone metabolism includes enterohepatic circulation. It can penetrate through the placental barrier and enter into breast milk. It also has effects of inhibiting estrogen and androgen synthesis.

Uses:  
 
It can be used as a kind of inefficient diuretic drugs. 
It is a synthetic 17-lactone steroid which is a kind of renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension and hypokalemia. 
The active metabolite of lactone; It can be used for the Inhibition of aldosterone biosynthesis. It can also be used as the blocker of the Quabain effect.

Our Delivery:







FAQ:

1)Location & Working Hours
We are an International source locate in China.
I will answer emails from Monday to Saturday, 8:30 am to 18:00 pm (GMT+8)

2)How long does it takes to get back a response from you?
You should receive a response in less than 24 hours.

3)How do I make an order?
When you choosed the products, please email me, and I will quote for you, if you are satisfied with it, then pay for it, the parcle will be sent for you as soon as possible.

4)How to track my order?
 After I ship your order and have the tracking number, you will receive an email notification. All tracking numbers I provide can be tracked at http://www.17track.net/en. Or you can ask me for helping you track it too.

5)How long does the whole process take, from making an order till receiving the package?
The package will be prepared within 1 working day after payment received and be sent out within 72 hours. 
The delivery time depends on the shipping situation and customs. 
The shipping time will not more than 15 working days at most.

6)How about  the shipping cost?
The shipping cost is for the whole order. No matter how many different items and quantity in one orders. The shipping cost will be charged only once.

7)Is there a minimum order?
For raw powder: MOQ is 10g
For oil liquid: MOQ is 50ml
For peptide vial: MOQ is 10 vials

8)Reship Policy
To U.S. We reship for free twice if your package gets seized. 
To other countries we reship for free once if your package gets seized. 
If you choose not to reship or the resent package failed to go through again, no refund will be made.

9)Payment Ways
We accept Bank Transfer(T/T ), Western Union, Moneygram, Bitcoin.
*** The Bitboin is a little special for us, our Bitcoin account is always changing, once I gave you the account number, please pay for it at once.  

10)Refund policy
Our company has a 2 reship policy all foreign countries in case of a seizure.
**We are not responsible if you throw away your products because you cannot find them in our disguised package. If you cannot find your products please email me and I will tell you where to find them.


More Hot Sale Products: