Beauty reveals the key secret of longevity of brain cancer cells
September 12, 2018 Source: Science and Technology Daily
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Researchers at the University of California, San Francisco found that a specific component of the GABP protein, LGABP-β1L, is an uncontrolled fragmentation and reproduction of glioblastoma cells associated with mutations in the telomerase reverse transcriptase (TERT) promoter. The essential. They published a paper in the journal Tumor Cell on the 10th, saying that the new findings provide a promising drug target that is important for future glioblastoma and other treatments for cancers associated with mutations in the TERT promoter. .
Longer than healthy cells, it is one of the important characteristics of tumor cells. Their number of divisions is not strictly restricted like healthy cells, so they can continue to divide and spread. Scientists believe that this ability of tumor cells may be related to mutations in the TERT promoter. The TERT promoter mutation is one of the three most common mutations in all human cancers and is the most common mutation in fatal brain cancer glioblastoma. Recent studies have reported that more than 50 cancers are caused by mutations in the TERT promoter. Other studies have shown that these mutations bind the GABP transcription factor to the TERT promoter and activate it, but in healthy cells, GABP and TERT are usually independent of each other.
This time, researchers at the University of California, San Francisco found that patients with glioblastoma with a TERT promoter mutation depend on GABP for survival. This protein is critical for the functioning of most cells, but one of the specific components, GABP-?1L, does not seem to be necessary in normal cells. When the researchers eliminated the GABP-1L from the cultured glioblastoma cells by means of CRISPR gene editing technology, the growth rate of tumor cells was significantly slowed down. Subsequent mouse experiments have shown that unedited glioblastoma cells derived from human patients grow rapidly after implantation in mice, which can quickly lead to death in mice; and lack of GABP- after genetic editing. 1L of tumor cells grow slowly in mice and their lethality is also low.
The researchers point out that GABP-?1L is a promising new drug target that is important for the treatment of glioblastoma and many other cancers associated with mutations in the TERT promoter. They will look for small molecule drugs that have similar effects to the gene editing techniques used in the experiment, and promote the treatment of related cancers.
The GABP protein is a key transcription factor that tumor cells use to continue life. Cancer cells are indeed embarrassing, it manipulates the resources necessary for life for its own use, and the path is diverse, does not depend on a certain link, so the target drug of cancer is only effective in a small range. But human beings have patience. Although they can't kill cancer in one fell swoop, they can be annihilated by small stocks. (Reporter Liu Haiying)
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