According to the British Broadcasting Corporation (BBC) and Reuters, the team of Evelyn Telfer, a reproductive biologist at the University of Edinburgh in the UK, first matured human egg cells from the early stages in the laboratory. About 10%. This means that human egg maturation is no longer solely dependent on female ontology. This achievement is of great significance for understanding human reproductive development and means that new treatment options for female infertility may occur. This result was published online in Molecular Human Reproduction.
The research team obtained small ovarian tissue from 10 females by caesarean section, and 87 follicles were isolated and cultured in nutrient medium for 21-22 days, and finally 9 mature eggs were obtained. Researchers believe the technology may provide new options for pre-pubertal female cancer patients to retain fertility. Because chemotherapy can damage the egg and cause infertility, adult women can cryopreserved the egg before treatment, but the pre-pubertal girl has not yet formed a mature egg, and may lose fertility opportunities forever. To this end, some people will choose to cryopreserve a small piece of ovarian tissue, which will be returned to the body to produce eggs in the future, but this may cause cancer to recur. This technique solves this problem by cryopreserving ovarian tissue prior to treatment, culturing mature eggs in vitro, and in vitro fertilization.
The results of this study have attracted wide attention from peer experts. While recognizing that it has made major breakthroughs, it also questioned whether the mature eggs it cultivated have complete biological functions. It is believed that further sperm fertilization experiments should be carried out to prove whether healthy embryos can be formed. . In addition, the time taken for the in vitro culture of the egg to be matured (22 days) was significantly shorter than the natural maturation time (5 months) in the body, and the polar body cells formed by meiosis during the experiment were abnormally large, and further investigations were needed to investigate the causes and effects. . (Technology Department)
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