Release date: 2016-01-21
One day, can we have bionic human body parts like Wolverine, can prevent diseases and injuries, and even heal itself? Although it seems to be just something in science fiction movies, there is such a breakthrough in medicine, and this future is not far away. An example of this is the new nanoshell therapy developed by the University of Michigan team.
The new technology discards the use of exogenous cells or molecules for repair and re-growth of damaged bone tissue. Instead, it uses polymer nanoshells, a microcapsule placed in the body to send tiny RNA molecules to the lesion. . When the nanoshell begins to decompose, the tiny RNA molecules are released, directing the surrounding cells to "activate" the natural osteogenic and healing mechanisms.
It's a bit like the project manager at the demolition site, directing construction workers to rebuild houses. 
This new technology has two key advantages. First, the nanoshell is designed to slowly decompose, so that the microRNA molecules can be gradually released, so the restorative treatment can be touched for one month or longer. Second, this process uses human own cells, rather than introducing an exogenous repair agent, to avoid cell rejection or tumors associated with injury.
This is important because, in theory, our bones contain everything that can be healthy and strong, but the healing process is not activated when needed, so there is continuous damage, tooth decay or osteoporosis. By handing over the task of managing the healing process to microRNAs, researchers hope that the restoration work can be sustained and thorough.
What's more, this special nanoshell makes it easier for tiny RNA to cross the cell wall and give orders. Principal investigator Peter Ma said: "The new technology we have studied opens the door to future use of DNA and RNA for regenerative medicine and to overcome other intractable diseases."
Although this technique has only been tested on mice, it is hopeful to be useful to humans as well, and this is what the researchers intend to do next. Ultimately, this self-healing treatment will be used to wait for orthopedic surgery or joint repair, and even dental caries (Ma himself is a professor of dentistry).
Growing and regenerating high quality bones for specific purposes has always been a challenging challenge, so the University of Michigan's new findings are full of potential. The mice used in the experiment suffer from osteoporosis, and there are nearly 75 million osteoporosis patients in Europe, the United States, and Japan, and their lives will be improved by this technology.
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Source: Omelette
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