Release date: 2018-03-14
Microscopy is a basic tool used by scientists in biological research. Under the microscope, scientists often see a given research material, such as cells. However, until now, the current microscopic method for exploring living brain cells. Limited to cells that are labeled prior to imaging, due to technical limitations, researchers cannot simultaneously label all cells in a particular region of the brain, which inevitably limits the ability of researchers to observe and study the progression of brain cells, while brain cells They are closely related and interact with each other.
Recently, a research report published in the internationally renowned magazine Cell entitled "Super-resolution imaging of the extracellular space in living brain tissue", scientists from the University of Bordeaux in France described a kind of research through research. The new microscope detection technology, called SUSHI, can effectively improve the imaging of brain cells in living brain tissue.
SUSHI technology, Super-resolution Shadow Imaging, enables brain cells that are infiltrated by liquids in a small space to be labeled all at once, so researchers don't need to analyze all cells individually. Considering that this "tag" is also located outside the cell, this technique of negative imaging is similar to that used in ancient cameras. Therefore, this negative imaging information contains the same information and details as the frontal image of the brain cells. Because the marking procedure is very simple and straightforward, it is easy for researchers to obtain the corresponding imaging information and related information.
Researcher Jan Tonnesen said that SUSHI technology is a revolutionary and innovative technology that helps us simultaneously image all brain cells in specific areas of living brain tissue. In the past, we only saw some blank areas in the microscope image. Because we can't mark all brain cells at the same time, this is a very big limitation for more in-depth research.
From now on, researchers can simultaneously observe and analyze the interaction of all cells in the microscope with the help of SUSHI technology, which can effectively accelerate the researchers' brain cells in healthy brain tissue and diseased brain tissue. Functional differences are being studied to provide clues and research basis for the development of new therapies for the treatment of related brain diseases; later researchers will use this new technology to conduct more types of research on brain cells through more in-depth research.
Microscopy is a basic tool used by scientists in biological research. Under the microscope, scientists often see a given research material, such as cells. However, until now, the current microscopic method for exploring living brain cells. Limited to cells that are labeled prior to imaging, due to technical limitations, researchers cannot simultaneously label all cells in a particular region of the brain, which inevitably limits the ability of researchers to observe and study the progression of brain cells, while brain cells They are closely related and interact with each other.
Recently, a research report published in the internationally renowned magazine Cell entitled "Super-resolution imaging of the extracellular space in living brain tissue", scientists from the University of Bordeaux in France described a kind of research through research. The new microscope detection technology, called SUSHI, can effectively improve the imaging of brain cells in living brain tissue.
SUSHI technology, Super-resolution Shadow Imaging, enables brain cells that are infiltrated by liquids in a small space to be labeled all at once, so researchers don't need to analyze all cells individually. Considering that this "tag" is also located outside the cell, this technique of negative imaging is similar to that used in ancient cameras. Therefore, this negative imaging information contains the same information and details as the frontal image of the brain cells. Because the marking procedure is very simple and straightforward, it is easy for researchers to obtain the corresponding imaging information and related information.
Researcher Jan Tonnesen said that SUSHI technology is a revolutionary and innovative technology that helps us simultaneously image all brain cells in specific areas of living brain tissue. In the past, we only saw some blank areas in the microscope image. Because we can't mark all brain cells at the same time, this is a very big limitation for more in-depth research.
From now on, researchers can simultaneously observe and analyze the interaction of all cells in the microscope with the help of SUSHI technology, which can effectively accelerate the researchers' brain cells in healthy brain tissue and diseased brain tissue. Functional differences are being studied to provide clues and research basis for the development of new therapies for the treatment of related brain diseases; later researchers will use this new technology to conduct more types of research on brain cells through more in-depth research.
Source: Bio Valley
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