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On May 12, local time, according to the British Daily Mail website "Mail online", the biotechnology startup "Rejuvenate Bio" co-founded by Harvard Medical School's top synthetic biologist and genetician George Church is working. Studying a rejuvenation technique, the company hopes to make dogs younger and one day may apply the same technology to humans.
The company said that the George Churh team had conducted initial experiments on a Beagle hound and found that they were able to make them more "young" by introducing new DNA instructions into their dogs. And if the study proves to be safe, 63-year-old George Churh himself will be the first to test.
In a video interview, George Churh revealed that the company's age reversal technology is based on previous research that has been tested on worms and flies, such as by modulating genes in simple organisms like them. The results show that they can double their lifespan.
Previous studies have also shown that transfusion of blood from older rodent mice to older mice can restore some biomarkers to a younger level.
"We have done some experiments on mice, we have done some experiments on dogs, and then we will continue to develop the application in humans," Church said earlier this year in a series on bioengineering. The anchor Rob Reid said.
Church hopes that the ultimate goal is to make humans "not only have a 130-year-old experience, but also have a body and spirit of 22 years old."
The company's research data has been kept secret, but according to documents obtained from the MIT Technology Review, the company has already had four pigeons at the Tuves Vetertics School in Boston. The dog underwent gene therapy.
Church pointed out that even if age-reversing gene therapy does not work for humans, it is still beneficial to develop this therapy for dogs.
Church said at an event in Boston last week: "The dog itself is a market. It is not just a mammal close to humans. It is also an animal that people in the pet world will pay for. For dogs, FDA approval The process is much faster than humans - more than a year, not about nine years. We will carry out the dog's aging reversal test, which will be a product, which will also increase the cost of human trials."
The company has received funding from the US Special Operations Command to study "enhance" the physical and combat effectiveness of military dogs.
First, the company hopes to extend the lifespan of Cocker spaniels and Doberman pinschers, which are prone to fatal heart disease. About half of these puppies will be 10 years old. A heart mitral valve disease is aborted, and Rejuvenate Bio's dogs can be free of these diseases by receiving gene therapy. Although the company did not disclose specific methods for treating dogs, the method was similar to that of George Church's lab in Harvard University using a new tool such as CRISPR to try rejuvenation in mice. The Church team has modified two genes through four different treatments that treat four major aging diseases (heart and kidney disease, obesity and diabetes). According to Church, the results were "very surprising and unexpected."
However, is the role of genetic modification to prevent disease or delay aging? According to Church, the difference between disease prevention and age reversal is whether an old dog's body can be as flexible as a young dog.
Of course, reversing the aging of pets has brought many ethical issues. What is the ethical line of experimentation on pets? If longer life means other negative health trade-offs, or unexpected side effects? What if the pet's life span exceeds the owner? However, now, Rejuvenate Bio must prove that it can indeed achieve its lofty goals (ie, prolong the potential of life).
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