Model NO.: CAS: 1626387-80-1
Maximum Monomer Impurity: ≤0.5%
Total Impurities: ≤1.0%
Heavy Metal: ≤20ppm
Appearance: Light Yellow Powder
Trademark: NJBN
Transport Package: 50g/Foil Bag; 25kg/Drum
Specification: 50g/foil bag; 25kg/drum
Origin: China
HS Code: 000000
Model NO.: CAS: 1626387-80-1
Maximum Monomer Impurity: ≤0.5%
Total Impurities: ≤1.0%
Heavy Metal: ≤20ppm
Appearance: Light Yellow Powder
Trademark: NJBN
Transport Package: 50g/Foil Bag; 25kg/Drum
Specification: 50g/foil bag; 25kg/drum
Origin: China
HS Code: 000000
99% Purity AZD3759 CAS: 1626387-80-1 for Treatment of cancerQuick Details of AZD3759Â :
Â
| Product Name | AZD3759 |
| Synonyms | AZD 3759;AZD3759;AZD-3759;(2R)-2,4-Dimethyl-1-piperazinecarboxylic acid 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester;HY-18750;azd3579;1-Piperazinecarboxylic acid, 2,4-dimethyl-, 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester, (2R)-;4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl (2R)-2,4-dimethylpiperazine-1-carb |
| CAS No. | 1626387-80-1 |
| Molecular Formula | C22H23ClFN5O3 |
| Molecular Weight | 459.91 |
| EINECS No. | 1592732-453-0 |
| Melting point | 192.4 °C in Alcohol, Ester; 193.3 °C in Water |
| Water solubility | Soluble in DMSO |
| Moisture | ≤0.5% |
| Maximum monomer impurity | ≤0.5% |
| Total impurities | ≤1.0% |
| Heavy metal | ≤20ppm |
| Appearance | Light Yellow Powder |
| Purity | 99% min |
| Quality Standard | Enterprise standard |
| Packing | 50g/foil bag;25kg/drum |
| Shipment | EMS;DHL;FedEx;TNT;UPS |
| Delivery Time | 4-7 Working Days |
| Payment terms | T/T;Western Union;Money Gram;Bitcoin |
| Usage | Treatment of central nervous system metastases lung cancer |
AZD3759Â Descriptions:
AZD3759 is a potent, orally active, CNS-permeable EGFR inhibitor with IC50 of 0.3 nM, 0.2 nM, and 0.2 nM for EGFR (WT), EGFR (L858R), and EGFR (exon 19Del), respectively. . AZD3759 inhibits EGFR phosphorylation with an IC50 of 7.2 nM. AZD3759 inhibited proliferation of PC-9 and H3255 cells derived from the pEGFR pathway and EGFR mutant genes with IC50 of 7.7 nM and 7 nM, respectively, and had no activity on the proliferation of H838 cells.
AZD3759Â Applications:
A phase 1 clinical trial of AZD3759 showed very good control activity of intracranial lesions. The dose of this drug was recommended to be 200mg or 300mg each time, twice daily. AZD3759 does not control extracranial lesions better than other EGFR-targeting drugs, but it has a greater advantage in the control of intracranial lesions.Patients with meningo-metastasis in this clinical trial can benefit from the treatment of AZD3759, and the 300 mg dose appears to be more likely to obtain greater control.
Our order process:
| Step 1 | Please tell me in what products you are interested including CAS number, quantities, and the destination country. |
| Step 2 | You confirm all details and offer us purchase order. |
| Step 3 | We offer the quotation of products and suitable shipping method for reference. |
| Step 4 | You confirm the order and pay money 100% in advance and send us your contact information including contacting person,address,mobile number etc. |
| Step 5 | We arrange the shipment according to your requirements and tracking number will be offered after confirming the payment within 24h |
| Step 6 | We offer after-sales service after you receive products. |
Our competitive advantages:
| Rich experience | Our company is a professional raw powder factory in China for over 10 years, all powders are factory directly supplying. |
| Wide range of export | Our products have exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Australia, Japan, Korea and many other countries, over 100kgs each month. |
| High customs pass guaranteed | Professional team special for package and shipment and staring on tracking code 24hours for customs pass guaranteed. 100% pass to UK, Norway, Poland, Spain, USA, Canada, Brazil; 98% pass to Germany, Russia, Australia, New Zealand. |
| Fast leading time | Most of powders are in stock, Chargeable samples are available, Could be shipped out within 24hours. |
| High quality, good price, fast and safety delivery | Shipment by EMS ,FEDEX,DHL,TNT, UPS ,etc |
Quick Details of AZD3759Â :
Â
| Product Name | AZD3759 |
| Synonyms | AZD 3759;AZD3759;AZD-3759;(2R)-2,4-Dimethyl-1-piperazinecarboxylic acid 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester;HY-18750;azd3579;1-Piperazinecarboxylic acid, 2,4-dimethyl-, 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester, (2R)-;4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl (2R)-2,4-dimethylpiperazine-1-carb |
| CAS No. | 1626387-80-1 |
| Molecular Formula | C22H23ClFN5O3 |
| Molecular Weight | 459.91 |
| EINECS No. | 1592732-453-0 |
| Melting point | 192.4 °C in Alcohol, Ester; 193.3 °C in Water |
| Water solubility | Soluble in DMSO |
| Moisture | ≤0.5% |
| Maximum monomer impurity | ≤0.5% |
| Total impurities | ≤1.0% |
| Heavy metal | ≤20ppm |
| Appearance | Light Yellow Powder |
| Purity | 99% min |
| Quality Standard | Enterprise standard |
| Packing | 50g/foil bag;25kg/drum |
| Shipment | EMS;DHL;FedEx;TNT;UPS |
| Delivery Time | 4-7 Working Days |
| Payment terms | T/T;Western Union;Money Gram;Bitcoin |
| Usage | Treatment of central nervous system metastases lung cancer |
AZD3759Â Descriptions:
AZD3759 is a potent, orally active, CNS-permeable EGFR inhibitor with IC50 of 0.3 nM, 0.2 nM, and 0.2 nM for EGFR (WT), EGFR (L858R), and EGFR (exon 19Del), respectively. . AZD3759 inhibits EGFR phosphorylation with an IC50 of 7.2 nM. AZD3759 inhibited proliferation of PC-9 and H3255 cells derived from the pEGFR pathway and EGFR mutant genes with IC50 of 7.7 nM and 7 nM, respectively, and had no activity on the proliferation of H838 cells.
AZD3759Â Applications:
A phase 1 clinical trial of AZD3759 showed very good control activity of intracranial lesions. The dose of this drug was recommended to be 200mg or 300mg each time, twice daily. AZD3759 does not control extracranial lesions better than other EGFR-targeting drugs, but it has a greater advantage in the control of intracranial lesions.Patients with meningo-metastasis in this clinical trial can benefit from the treatment of AZD3759, and the 300 mg dose appears to be more likely to obtain greater control.
Our order process:
| Step 1 | Please tell me in what products you are interested including CAS number, quantities, and the destination country. |
| Step 2 | You confirm all details and offer us purchase order. |
| Step 3 | We offer the quotation of products and suitable shipping method for reference. |
| Step 4 | You confirm the order and pay money 100% in advance and send us your contact information including contacting person,address,mobile number etc. |
| Step 5 | We arrange the shipment according to your requirements and tracking number will be offered after confirming the payment within 24h |
| Step 6 | We offer after-sales service after you receive products. |
Our competitive advantages:
| Rich experience | Our company is a professional raw powder factory in China for over 10 years, all powders are factory directly supplying. |
| Wide range of export | Our products have exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Australia, Japan, Korea and many other countries, over 100kgs each month. |
| High customs pass guaranteed | Professional team special for package and shipment and staring on tracking code 24hours for customs pass guaranteed. 100% pass to UK, Norway, Poland, Spain, USA, Canada, Brazil; 98% pass to Germany, Russia, Australia, New Zealand. |
| Fast leading time | Most of powders are in stock, Chargeable samples are available, Could be shipped out within 24hours. |
| High quality, good price, fast and safety delivery | Shipment by EMS ,FEDEX,DHL,TNT, UPS ,etc |
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