A new study by researchers at King's College London found that diabetic patients with early kidney disease lack a protective "anti-aging" hormone, Klotho.
A study published today in Diabetologia (European Diabetes Research Association (EASD)) suggests that Klotho may play an important role in the development of kidney disease in diabetic patients.
This may mean that Klotho levels have the potential to be used as markers to predict the risk of kidney disease and to develop new treatments to prevent kidney disease in patients with type 1 diabetes.
Previous work at King's College also showed that Klotho protects the vascular system from changes associated with abnormal aging, such as thickening of the arterial wall (atherosclerosis), which characterizes age-related diseases such as diabetes, heart disease and high blood pressure.
In this study, scientists tested blood and urine samples from 78 patients with type 1 diabetes, and 33 of them also showed signs of early stages of diabetic nephropathy called microalbuminuria.
They found that patients with microalbuminuria had lower levels of circulating Klotho hormones compared with patients without microalbuminuria. Klotho levels in patients without microalbuminuria are similar to those found in healthy adults.
The first author of the study, Dr. Giuseppe Maltese from the Department of Cardiology at King's College London, said: "The first discovery of Klotho is associated with kidney disease in patients with type 1 diabetes. This finding represents the development of new markers and potential new treatments. Born."
Senior author Dr. Janaka Karalliedde said: "We hope to expand the scope of this work to identify early-stage high-risk patients with kidney disease and cardiovascular disease."
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