Causes of systemic lupus erythematosus
November 5, 2018 Source: Science and Technology Daily Author: in chawol
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Systemic lupus erythematosus is a chronic and difficult disease involving multiple organs of the body. It used to be considered an "incurable disease". Because its pathogenesis is unknown, diagnosis and treatment are difficult, and there is no effective treatment and it cannot be cured.
Recently, Liu Wanli, a researcher at the School of Life Sciences at Tsinghua University, and Li Zhanguo, director of the Rheumatology and Immunology Center at Peking University People's Hospital, discovered a molecular variation in the presence of human immunoglobulin to increase the susceptibility to systemic lupus erythematosus, and this mutation is involved in the regulation of immune B cells. . In short, the two teams confirmed that an abnormal immune molecule in the human body is an important cause of the onset of systemic lupus erythematosus. The research results have been published in the journal Science.
According to Sun Xiaolin, one of the authors of the article, Peking University People's Hospital, Li Zhanguo collected nearly 2,000 large samples of patients with systemic lupus erythematosus and studied it. It was found that patients with immunoglobulin mutations produced pathogenic cells and a wide variety. The incidence and severity of inflammation, such as nephritis, arthritis, serositis, and vasculitis, are significantly increased. Through various research methods such as immune cell tracing, animal testing, and sequencing, Liu Wanli found that the immune molecule mutation activates the immune signaling pathway and promotes the pathogenic mechanism of B cells secreting various autoantibodies.
The reporter learned that the two teams have joined forces to give full play to their respective advantages and achieved a close integration between basic research and clinical application. Liu Wanli team is committed to B lymphocyte immune recognition and immune activation research, and the Li Zhanguo team has long been engaged in the clinical study of systemic lupus erythematosus. "This research is one of the results of years of cooperation between the two teams. It is also the first time in the academic community to recognize that immunoglobulin gene abnormalities will induce systemic lupus erythematosus, which will lay a solid foundation for further academic research and clinical targeted therapy. Foundation." Sun Xiaolin said.
Feline Infectious Peritonitis (FIP), referred to as Feline Infectious Peritonitis (FIP), is a fatal abnormal immune response that occurs in cats. It is caused by the mutation of the feline coronavirus carried by cats. As a high-incidence and fatal disease of pet cats, the current incidence of feline abdominal transmission is about 10%.
The symptoms of cats are usually divided into two categories, namely wet FIP and dry FIP, of which wet FIP accounts for the majority of all cases. About 70%, manifested as abdominal pleural effusion, abnormal bulging; dry FIP cats have different symptoms, depending on the type of organ affected by the virus.
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