According to a recent clinical trial, stem cell transplantation can help patients with Crohn's disease reshape the immune system. As we all know, the above diseases are a very painful type of chronic intestinal inflammation, and at least 115,000 people in the UK are currently suffering from the disease.
Crohn's disease triggers a long-term inflammatory response to the digestive tract, leading to long-term diarrhea, abdominal pain, extreme fatigue, and other symptoms that significantly affect quality of life.
Current therapies for these diseases include reducing the inflammatory response through drug therapy, but the effect of this therapy is not stable, and it is often necessary to surgically remove the lesion. In extreme cases, patients will undergo many surgeries in a few years.
The use of stem cell transplant technology to replace a patient's immune system has recently been found to be successful in the treatment of multiple sclerosis. In this trial, the authors hope to see if similar inflammatory responses can be reduced in the intestinal tract of patients with Crohn's disease.
In this trial, patients received chemotherapy and hormonal therapy to activate stem cells in the body, which was then obtained by blood separation. Further chemotherapy is used to remove the immune system from the body. Finally, the stem cells are returned to the patient. The patient eventually develops a completely new immune system.
Although the study is still ongoing, the results are still unclear, but the researchers believe that this treatment is expected to reduce the degree of inflammation in patients and ultimately achieve a healing effect.
Information source: Stem cell transplants to be used in treating Crohn's disease
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