Researchers at the University of Toronto in Canada have found an important part of the laboratory's own development of human tissue, which will be of great help in repairing or replacing damaged human organs in the future. The so-called "on-chip human-like tissue" technology will also become a powerful new tool for drug testing, making it possible to conduct drug testing in the human body safely and flawlessly.
The "AngioChip" human tissue patch developed by the researchers connects multiple human organs in vitro through an internal artificial vascular access. These mini-channels work like a jigsaw puzzle to inlay "blocks" together, not only to connect the two artificial organs, but also to evaluate their interactions.
To incorporate these biodegradable patches, Zhang Boyang, a Ph.D. student in the Department of Chemical Engineering at the University of Toronto, used a new 3D printing technology based on computer microchip design to create a tissue that is the size of a female fingernail. Like a “human body†building block toy, Zhang Boyang manually stacks these biodegradable layers together. Each layer is printed with a unique POMaC polymer and embedded with a thin vascular channel like a human hair. After the construction is completed, the parts are "bonded" together with ultraviolet light.
These structures are immersed in a solution containing active cells, and when rapidly grown, they can simulate various cells in human organs. So far, researchers have developed heart and liver models. After implanting the microchip into the mouse, the researchers even observed that the blood of the mouse could flow smoothly without condensation in the artificial blood vessel, which is no different from the flow in natural blood vessels.
At the same time as the commercialization of technology, Zhang Boyang said that the next step is to evaluate how long the chip can last in the body before it is disintegrated or naturally absorbed, and through technical upgrades, the "AngioChip" human tissue patch is manually assembled from the current. Gradually transition to automated production.
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