Release date: 2014-04-23
Researchers at Bayland University in Israel have successfully used DNA strands to create a nano-robot that performs logical operations in a moving object in accordance with a programmed program, like a nano-robot computer.
Researchers at Bayland University in Israel have successfully used DNA strands to create a nano-robot that performs logical operations in a moving object in accordance with a programmed program, like a nano-robot computer. The physicist organization network recently reported the results of this research. The researchers injected these "robots" into the sputum and observed how they "targeted" a cell to "work." Related papers were published in the recently published Nature·Nanotechnology.
A biological system is a collection of "molecular parts" that move around and collide with each other. Cells perform complex task processes by precisely controlling these collisions. But it is still very difficult to develop an artificial machine that can interface with the machines in the cell and control the interaction between the molecular parts. And DNA molecules not only naturally interface with biological systems, but also the natural "base" of logical operations.
Previous studies have shown that because DNA strands have the property of reacting with different proteins, they can be used to program simulated biological circuits and even solve simple mathematical problems. The research team has shown that this programming technique can also be extended to active objects to perform special tasks, such as destroying cancer cells.
The researchers first untied the DNA double helix strands that were coiled together, then connected them together in a folding carton, and then loaded a chemical molecule into the "DNA box" as a medium Following the switch. The next step is to make "parts" of other structures that allow them to react with the "box" and react with certain specific proteins in the body. The overall goal is to make a variety of options to allow the "box" to automatically open when it encounters a particular protein. Adding a variety of nano-"parts" allows the "box" to be selectively opened.
For example, let the "box" open only when it encounters three kinds of proteins, one of which is the natural protein in the cockroach, and the other two are carried by two different DNA folding parts. Mixing together various forms of the result, the result "box" can be determined by logical operation to open or not, such as "and" or "or" (if a certain protein appears, the "box" will not open) Etc. This means that they can operate logically within the active object.
In the experiment, the researchers placed a "DNA box" with a chemical molecule that binds to the hemolymph molecules, which are found in blood stasis. All nanobots are filled with fluorescent markers to track their movements in the sputum.
According to the researchers, the experiment was run as pre-conceived: the opening of the "DNA box" depends on the design of the overall nano-robot "fleet" injected into the sputum. They demonstrate a variety of logic gates, including AND, OR, XOR, NAND, NOT, CNOT, and half adder. The research team believes that in the next five years, people may create nano-robot computers for human experiments.
Source: Kexun
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