Recently, researchers have confirmed through experiments that fat cells can “talk†to organs by transmitting molecular information and managing genes in distant organs such as the liver. This finding will be of great significance in the treatment of type 2 diabetes and obesity.
The discovery was published in the February 15 issue of the British journal Nature. Thomas Thomou, a researcher at Harvard Medical School and the Joslin Diabetes Center, led his team to confirm that adipose tissue can release tiny molecules to communicate with body organs.
Specifically, fat will "send" the miRNA, the messenger carrying information, and reach the distant organs through the exogenous "communication ship" and regulate it. The role of fat in regulating metabolism is higher than scientists thought before, which opens up new research ideas for communication between cells. At the same time, because of the ability to develop gene therapy using fat cells, this new finding also provides new options for the treatment of some diseases, such as type 2 diabetes and obesity.
Robert Freishtat, a children's health system from Washington, DC, is a pediatrician and a researcher on metabolic diseases such as diabetes and obesity, but he is not involved in the latest study. According to Frestatte, scientists have long known that fat is associated with the development of various diseases, but does not fully understand how adipose tissue affects distant organs and their functioning.
Previously, scientists only knew that fat releases hormones and reminds the brain to manage appetite, but recent research suggests that there may be another “signal difference†in adipose tissue: a substance called miRNA (microRNA), which is a genetic material. A small piece in the middle.
What are miRNAs and exosomes?
Explain miRNA, starting with the working process of the living body. DNA is the "Commander" responsible for guiding biological development and vital functioning, but specific biological functions are performed by proteins. Therefore, DNA needs to be first transcribed into RNA and then translated into proteins by RNA. This process is called gene expression, in which RNA acts as an intermediary.
The relationship between DNA and RNA. WeChat public number
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