Pharmacological effects
The use of wild ramie extract coagulation soaked in large, artificial wounds on the tail of the mouse can reduce the amount of bleeding and shorten the bleeding time; the same effect can be obtained if the mice are given orally or intraperitoneally. After intramuscular injection of blood coagulation in rabbits, clotting time was shortened, but no significant change in platelet count was observed. The hepatic and renal wounds of rats were covered with cotton wool impregnated with blood coagulation, and no obvious hemostasis was observed. From the research on the components of ramie, it was found that caffeic acid has obvious hemostatic effect, so artificially synthesized hemagglutinic acid amine (caffeic acid diethylamine salt), rabbit intravenous injection of 7mg/kg, or mice intraperitoneal injection of 10mg /20g, coagulation time and bleeding time were significantly shortened, hemagglutinamide no antifibrinolytic effect in vitro, but mice irradiated with 60Co can significantly increase white blood cells and platelets.
Toxicity: The toxicity of hemagglutinamide is very low. The LD50 in mice injected intraperitoneally is 1583±80mg/kg. Intravenous injection of rabbits had no significant effect on blood pressure and respiration, and there was no change in electrocardiogram and liver and kidney function on continuous intravenous injection for 10 days.
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