Japanese team found that enzymes that promote apoptosis can regenerate nerves
August 09, 2018 Source: World Wide Web
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];According to a report by Japan’s Kyodo News Agency on August 7th, the research team of Miki Biology, Professor of Molecular Biology at Nagoya University in Japan, published a report on the online edition of the British Science Journal on the 6th that the use of nematodes to prove that it has the useless cells in the body The enzyme that dies and excludes it has the effect of promoting regeneration of the severed nerve.
Nerve cells transmit electrical signals to other nerve cells, muscles, etc., using elongated elongated "axons". If the axon is cut off due to injury or the like, the function as a nerve will be lost. Although there is also a case of regeneration, the detailed mechanism has not been known before. The research team expects this result to lead to the development of injured nerve regeneration therapy.
The team used lasers to cut axons from the nematode nerve cells and observe them. A detailed investigation of the axon-regenerating nerve cells revealed that Caspase, which destroys various proteins during apoptosis, acts to release a lipid "phosphatidylserine" produced by apoptosis. "(PS).
At this time, Caspase destroys only a part of the nerve cell protein, the cells do not apopulate, and PS binds to proteins related to regeneration on the cell membrane. According to analysis, the combination of PS promotes axonal regeneration.
Kyumoto said: "It has been known that nerve cells are regenerated through 'armor death'. If the detailed mechanism can be clarified, the future may contribute to the treatment of spinal cord injury."
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