Lipidomics technology reveals the scientific principles of cupping therapy

Release date: 2018-02-24

What scientific basis and principle of action for Chinese medicine cupping treatment? On the 22nd, the Science and Technology Daily reporter learned from the Second Affiliated Hospital of the Army Military Medical University (Chongqing Xinqiao Hospital) that the team of the Institute of Cancer Research, Li Yusheng, took the lead in using the mouse cupping model and established by ultra-high performance liquid chromatography-mass spectrometry. The lipid metabolomics platform reveals the changes in the anti-inflammatory/pro-inflammatory lipid metabolism profile induced by cupping therapy, and provides scientific support for the potential mechanism of cupping therapy. The research paper was published in the journal Cell Physiol Biochem on the 20th.

It is understood that in previous reports, cupping therapy researchers focus on skin temperature improvement, blood pressure, thermal effects, and blood oxygen content or objective perception scores of subjects. The team used a mouse cupping model and a lipid metabolomics platform established by ultra-high performance liquid chromatography-mass spectrometry to find anti-inflammatory lipids in healthy mice after cupping (eg PGE1, 5,6-EET, 14 , 15-EET, 11 10S, 17S-DiHDoHE, 17R-RvD1, RvD5 and 14S-HDoHE), markedly elevated, while pro-inflammatory lipids (such as 12-HETE and TXB2) were significantly down-regulated.

Through in vitro experiments, the team further found that cupping therapy can reduce the production of proinflammatory mediators TNF-α and IL-6 in the peritoneal fluid of lipopolysaccharide-induced peritonitis mouse model. This study shows that cupping can cause an increase in anti-inflammatory and anti-regressive lipid components in the body, and the reduction of pro-inflammatory lipids provides a scientific basis for promoting immune homeostasis.

Source: Technology Daily

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