Release date: 2014-12-08
According to South Korea's "Central Daily News" on December 3, the Korean research team used porcine valves to develop a heart valve similar to human tissue. This is the first time in the world to develop a heart valve that does not produce rejection. The research team plans to begin pulmonary valve transplantation from the human body in 2015.
Seoul University Hospital Ren Hongguo, Professor Jin Rongzhen and Professor Jin Jipan's research group announced on the 2nd that they have developed a porcine valve that has been treated with a rejection-free reaction and transplanted it to more than 10 sheep, confirming the stability and effectiveness of the valve. Sex. It is understood that the size of the internal organs of pigs is similar to that of humans and is therefore a source of supply for human transplant organs. The problem is that mammals have a glycoprotein called Alpha-GAL, and the body has Alpha-GAL antibodies. For this reason, after transplanting the porcine valve into the human body, the antibody attacks Alpha-GAL, resulting in a calcification reaction. In the current heart valve surgery, although a tissue valve composed of living tissue of pigs is also used, a second operation is required due to a calcification reaction.
The research team focused on removing Alpha-GAL. The research team then used the self-developed anti-calcification tissue treatment method to treat the aortic valve of the pig and successfully developed a heart valve without Alpha-GAL. Since December 2011, the research team has transplanted the valve to the mitral valve of 10 sheep. After 18 months of observation, the body of all 10 sheep maintained normal function. Ren Hongguo said, "The calcification and degenerative changes were not found in all examinations such as radiation, microscopy and biochemistry."
Source: World Wide Web
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