Original title: Scientists found that the "significant old" gene [ China Pharmaceutical Network Health Health ] on the road, the author was mistaken by many people as a middle school student, looked helpless. When it comes to the age of appearance, we can easily think of the comparison between Lin Zhiying and Guo Degang who were very angry on the Internet. This gap... Why is there such a big gap? A study published in Current Biology magazine for the first time reveals at the genetic level why some people seem to differ greatly from their actual age. 
Researchers at the Beijing Genomics Institute of the Chinese Academy of Sciences, the Erasmus University in the Netherlands, and the Unilever Group in the United Kingdom, in collaboration with other countries, have collaborated on a large-scale scientific study of skin-aware age genetic factors. In this project, scientists shared nearly 100,000 people to repeatedly evaluate the high-definition photos of more than 4,000 people, accurately quantify each person's perceived age (that is, the degree of youthfulness), and analyzed nearly 8 million The relationship between DNA sites and perceived age.
For the first time, the study found a link between perceived age and genes, and found that people with specific genotypes of the MC1R gene appear to be two years older than their peers. This discovery is expected to quickly increase our understanding of perceived age.
The MC1R gene is a key gene in the process of synthesizing melanin in human skin. Its genetic defect can cause the skin to lack the natural protective function of melanin, which leads to more UV light causing various damage to the skin in the long term, and may also cause skin cancer.
"The melanin synthesis function of the MC1R gene is only a small part of its influence on the age of perception." Liu Fan, a researcher at the Beijing Institute of Genomics, Chinese Academy of Sciences, said that the data show that the MC1R gene does not affect the perceived age. Affected by factors such as skin color, UV damage and exposure to sunlight, MC1R has other functions that play a key role. It is known that the cellular functions involved in MC1R also include oxidative damage, DNA repair and immune regulation, which may It is the cause of perceived age changes."
Researcher Liu Fan also pointed out that "this study found that multiple functional alleles in MC1R interact through the special way of compound heterozygotes. In the next step, we will use our latest method to target complex heterozygotes. A comprehensive test at the genome level is expected to find more genes that affect the age of perception."
Figure 1. The effect of wrinkle and non-wrinkle factors on facial perception age. Figure 2 shows the age-related MC1R gene region found in the Rotterdam population cohort.
Researchers at the Beijing Genomics Institute of the Chinese Academy of Sciences, the Erasmus University in the Netherlands, and the Unilever Group in the United Kingdom, in collaboration with other countries, have collaborated on a large-scale scientific study of skin-aware age genetic factors. In this project, scientists shared nearly 100,000 people to repeatedly evaluate the high-definition photos of more than 4,000 people, accurately quantify each person's perceived age (that is, the degree of youthfulness), and analyzed nearly 8 million The relationship between DNA sites and perceived age.
For the first time, the study found a link between perceived age and genes, and found that people with specific genotypes of the MC1R gene appear to be two years older than their peers. This discovery is expected to quickly increase our understanding of perceived age.
The MC1R gene is a key gene in the process of synthesizing melanin in human skin. Its genetic defect can cause the skin to lack the natural protective function of melanin, which leads to more UV light causing various damage to the skin in the long term, and may also cause skin cancer.
"The melanin synthesis function of the MC1R gene is only a small part of its influence on the age of perception." Liu Fan, a researcher at the Beijing Institute of Genomics, Chinese Academy of Sciences, said that the data show that the MC1R gene does not affect the perceived age. Affected by factors such as skin color, UV damage and exposure to sunlight, MC1R has other functions that play a key role. It is known that the cellular functions involved in MC1R also include oxidative damage, DNA repair and immune regulation, which may It is the cause of perceived age changes."
Researcher Liu Fan also pointed out that "this study found that multiple functional alleles in MC1R interact through the special way of compound heterozygotes. In the next step, we will use our latest method to target complex heterozygotes. A comprehensive test at the genome level is expected to find more genes that affect the age of perception."
Figure 1. The effect of wrinkle and non-wrinkle factors on facial perception age. Figure 2 shows the age-related MC1R gene region found in the Rotterdam population cohort.
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