ctDNA - clues
ctDNA (Circulating tumour DNA). ctDNA is a type of cfDNA (cell-free DNA), which is generally derived from apoptotic lysed cells. The free DNA released by the tumor cells to the blood is ctDNA.
Several studies have shown that the concentration of ctDNA is highly correlated with tumor progression, so we can use ctDNA for tumor staging, prognosis assessment, and dynamic drug resistance monitoring. The tumor genomic information it carries can be used for medication guidance, not only for simple sampling, but also to overcome the heterogeneity of tumor tissue in time and space, and to display more comprehensive information.
Crowley, E. Et al. Nat. Rev. Clin. Oncol. 2013
CTC - the evil leader
As solid tumors grow, certain tumor cells will acquire abnormal activity (epithelial interstitial transformation, EMT) when specific changes occur in the surrounding microenvironment. These cells, like evil squadrons, fall off the primary tumor and look for new places in the body. The exfoliated tumor cells on the blood fast line are called Circulating Tumor Cells (CTC).
At present, the CTC count can be used to judge prognosis and recurrence detection; single cell sequencing of CTC can guide tumor medication, master the dynamic changes of cancer, and timely adjust the treatment plan; live CTC isolated from blood can be further cultured Used to construct tumor research models and the like.
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