Diabetes is a metabolic disease characterized by hyperglycemia, which seriously affects human health. At present, type I diabetes requires frequent injections of insulin. Type II diabetes requires long-term use of hypoglycemic agents, but these treatments may also lead to insulin resistance, hypoglycemia, and loss of blood sugar. Therefore, it is necessary to break through the traditional blood sugar control ideas and develop new products that do not use insulin or sugar-reducing drugs to treat diabetes. On May 16th, a new result of "controlling sugar by sugar" was published in the top chemical journal "American Chemical Society". Xiao Yufen and Sun Hui, graduate students of Polymer Materials Department of Tongji University, were the first authors of the paper, and Professor Du Jianzhong was the newsletter. Author.
It is understood that under normal circumstances, the liver converts excess glucose into glycogen, and converts glycogen to glucose when needed, a process that is regulated by insulin. Inspired by this, the Department of Polymer Materials of Tongji University and the professor of Shanghai Tenth People's Hospital and the expert of Shanghai “Thousand Talents Program†Du Jianzhong designed a polymer vesicle (also known as nano-sugar) that can “breath†sugar. Sponge"), which automatically "sucks" glucose and stores it when blood glucose levels rise, and automatically "exhales" glucose when blood glucose levels drop, thereby maintaining blood sugar stability. Animal experiments have shown that injection of a vesicle maintains a two-day blood glucose balance. In general, patients with type 1 diabetes have multiple injections of insulin every day. The blood glucose regulation function of the vesicle is achieved by the dynamic replacement of the sugar polymer on the vesicle and the glucose in the blood with the lectin on the vesicle, ie "treating sugar with sugar". The vesicle has a similar blood sugar regulation function as the liver, and has long-term glycemic regulation effects on different types of diabetes, and is independent of insulin. In addition, the vesicles have significant size changes during the "breathing" of glucose and can be used for sensitive monitoring of blood glucose.
This kind of vesicles that do not use insulin or eat hypoglycemic drugs have opened up new ideas for the treatment of diabetes with sugar.
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