The Chinese scientist Zhang Feng’s god has swiped again. Professor James Collins and his team, co-transformed into the CRISPR-Cas13a sensitivity of the Côtes-level (aM, negative 18 power of 10 moles per liter), can detect a single molecule of SHERLOCK technology. This important achievement was published in the journal Science today.
Just when everyone is cheering for Zhang Feng, when they are clamoring for CRISPR-Cas13a. We've found SHERLOCK technology has reached the Côtes-level sensitivity is not CRISPR-Cas13a, is its partner, another subversive invention of recombinant polymerase amplification (Recombinase Polymerase Amplification, RPA). Few reports mentioned her, she stood silently behind the CRISPR-Cas13a.
How powerful is RPA? It is said to be comparable to PCR technology. What is PCR? Since the famous inventor Kary Mullis invented the technology to get the Nobel Prize in 1993 ...... It is understood that RPA technology was developed by UK technology company TwistDx invention, the inventor Niall A. Armes and Derek L. Stemple. If the invention of Professor Zhang Feng and Professor Collins can ultimately benefit humanity, we should also remember the inventor of RPA.
Next, let's take a look at how RPA and CRISPR-Cas13a team up to create SHERLOCK technology.
Professor Jennifer Doudna
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