According to past medical theory, the human body only has the central nervous system including the brain and spinal cord to perceive and analyze the perceptions of pain and cold. But a new study found that the presence of a “mini brain†in the peripheral nervous system can also sense and regulate pain signals, which may help develop non-addictive new analgesics.
The peripheral nervous system refers to all nerve structures except the brain and spinal cord, including ganglia, nerve trunk, nerve plexus and nerve endings. It contacts the central nervous system and other systemic organs, the main component of which is nerve fibers.
Researchers at the University of Leeds in the UK and Hebei Medical University in China have found that the ganglion in the peripheral nervous system of rodents can control the amount of information transmitted to the central nervous system in addition to conducting nerve signals.
The study found that these ganglion cells can transmit information to each other through a signaling molecule called GABA, which was previously thought to be only available in the central nervous system. Related papers have been published in the monthly magazine Clinical Examination Journal.
Research project director and professor of neurology at the University of Leeds, Nikita Gamper, said that although it is unclear how the peripheral nervous system specifically changes the information transmitted to the brain, it can sense and change tactile signals such as pain, hot and cold, etc. The facts, and this phenomenon should exist in humans as well.
Gampper believes that this new study is enough to challenge the "gating theory" proposed by Canadian neurophysiologist Ronald Melzac in the 1970s and 1980s. This theory holds that there are some "gates" between the peripheral nervous system and the central nervous system that can control which pain signals enter the brain. For example, when a person concentrates on running, he accidentally falls, and when he stands up, he continues to run. He may not feel pain, because some cells in the spinal cord prevent pain information from entering the brain, and the brain cannot perceive it. This is the "gating theory." The phenomenon explained.
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