Recently, a paper was published in the Nature issue, Nature Methods, and it was immediately reported by the official website of Science. This is a privilege to be enjoyed by heavy news. This research, which was followed by two leading academic journals, was written by Professor Ed Boyden, a well-known scientist at MIT. His team's "brain multiplication" has expanded the brain size by a factor of 20, allowing neuroscientists to observe brain structures at very high resolutions under normal light microscopy and even clearly distinguish between different synaptic proteins. .
For biologists, simply amplifying a biological sample is enough to get a lot of new knowledge. A few hundred years ago, microscopes let humans know the existence of cells. Today, more advanced microscopes allow scientists to see how different proteins work in cells. In the face of the ever-changing technological development, Professor Boyden, who studies brain and cognitive science at the MIT Department of Bioengineering, has a new idea. “We want to understand the layout of the entire brain circuit,†he said. “If you can reconstruct a complete brain circuit, you might use a computational model to understand how the brain produces emotions or make decisions. When you understand By the layout of each biomolecule, how the cells produce electrical signals, and how to exchange chemicals, you have the ability to simulate the entire brain."
â–² Professor Ed Boyden is one of the founders of optogenetics and is therefore well known to the world (Source: MIT)
However, the brain itself is not an organ suitable for observation. It is generally opaque and the arrangement of cells and cells is complex. Using existing confocal microscopes, scientists can observe resolutions up to a few hundred nanometers.
â–² Scientists hope to one day restore the layout of the entire brain circuit (Source: Science)
If it is too difficult to directly observe these organizations, why can't we make these organizations bigger? Scientists at MIT came up with a material called polyacrylate. This is a class of highly water-absorptive molecules, one of the most common uses being baby diapers. After absorbing the baby's urine, its volume will expand many times. Researchers have realized that this feature may be used to expand the volume of brain samples.
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