Release date: 2014-12-16
Recently, researchers from Brunel University have developed a new treatment for the treatment of cancer and degenerative diseases by using a nanoparticle. At the same time, it does not cause any side effects on the patient's body. Journal of Nanomedicine: Nanotechnology, Biology and Medicine.
Nowadays, we have made great progress in the use of nanomedicine, and researchers have found proteins in the blood that can disguise nanoparticles so that nanoparticles can be absorbed into cells without causing inflammation and destroying healthy cells.
In the article, researcher Uday Kishore said that carbon nanotubes (CNTs) can target the chain reaction of the complement system, which is part of the body's innate immune system and is responsible for cleaning up pathogens and toxins. When the entire complement system of the body is activated, from the beginning of C1 to the end of C5, the cell killing membrane attack complex is activated. In principle, this can trigger acute allergies and inflammatory reactions, but the opposite is true.
The reaction between CNTs and C1q is an anti-inflammatory response, and C1q is a complementary starter protein, suggesting that "coated" nanoparticles or healthy tissues carrying complement proteins reduce tissue damage and help treat inflammatory Diseases such as Parkinson's disease, Huntington's disease, and Alzheimer's disease.
Using the data from this study, this coated protein-coated carbon nanoparticle may be used to target glioblastoma; finally, Uday Kishore, a researcher, uses proteins recognized by the immune system to effectively disguise carbon nanoparticles. We can use these nanoparticles to target the body's hard-to-reach body without any side effects. This new nanoparticle will help us develop new therapies for cancer treatment in the future.
Source: Bio Valley
Intermediate – Intermediate: A material produced during a drug substance processing step that must undergo further molecular modification or refinement to become a drug substance. Intermediates may or may not be isolated. Intermediates are the key products of the previous process of making APIs, which are different in structure from APIs.
for example:
Amoxicillin capsules are called preparations, amoxicillin is called API, and 6-APA is called intermediate.
Ceftriaxone sodium powder is called preparation, sterile ceftriaxone sodium is called API, and 7-ACA is called intermediate.
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Intermediate is a very important type of fine chemical products. Its essence is a type of "semi-finished product", which is an intermediate product in the production of certain products. For example, if a product is to be produced, it can be produced from intermediates, saving costs and reducing It is widely used in the synthesis of medicines, pesticides, coatings, dyes and spices. In the field of medicine, intermediates are an important link in the industrial chain of the pharmaceutical industry. They are used for some chemical raw materials or chemical products in the process of drug synthesis. In a word, they are used to produce APIs.
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