Since 2000, there have been a number of major technologies affecting the future in the field of biotechnology: human genomics /proteomics, stem cell technology and tissue engineering, bioinformatics, transgenic technology, cloning technology, biochip/protein chip/tissue chip, gene Treatment and cell therapy, antisense nucleic acid technology, monoclonal antibody technology, etc. These technologies have greatly contributed to the modern life sciences and biotechnology industries.
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According to Datamonitor's "2010 Biotechnology Industry Overview" report, from 2005 to 2015, the global biotechnology market maintained a steady upward trend. Affected by the financial crisis, the growth rate of output value declined in 2009, but still achieved a growth rate of 4% compared with the previous year, totaling 2009 billion US dollars. In 2014, the global biotechnology market reached US$318.4 billion, up 58.5% from 2009.
The bio-industry mainly includes biomedicine, bio-agriculture, bio-energy, bio-manufacturing, bio-environment and other industrial fields.
Biotechnological drugs derived from organisms, used for in vivo diagnosis, treatment or prevention, produced by genetic engineering, antibody engineering or cell engineering, have become the most important products in the biotechnology industry. According to the Datamonitor report, biomedicine still holds the largest share of the global biotechnology market in 2009, reaching 66.3% of the industry. In the past decade, the bio-pharmaceutical industry has become the fastest growing, most energetic and technologically advanced field in the pharmaceutical industry, and its development rate is significantly higher than the average level of the pharmaceutical industry. According to data released by the International Monetary Fund (IMS) in 2010, the total sales of the global pharmaceutical market in 2009 was 815 billion US dollars, of which sales of bioengineered drugs and biochemical drugs totaled 130 billion US dollars, accounting for 15.9%. Among them, the three best-selling biotech drugs are monoclonal antibodies, vaccines, and tumor necrosis factor inhibitors (TNF). Among the top ten best-selling drugs in the world, biotechnology drugs account for half of the total, and among the top 20 drugs in the best-selling drugs, biotech drugs also account for 8 seats. Of the more than 100 biotech drugs approved by the US FDA, 30% are blockbuster drugs, while in non-biotech drugs, the ratio is less than 1%. It can be seen that biotechnology drugs have huge market demand and very high concentration.
With the rapid development of the bio-industry, the requirements for preservation, packaging and transportation of biotechnology products are increasing. The vacuum freeze-drying technology can maintain the original physical and chemical properties and physiological activity of the biological preparation, the loss of the active ingredient is extremely small, the lyophilized preparation has little water content, and is easy to be stably stored for a long time; and the loose porous structure peculiar to the lyophilized preparation can make the medicine easy Re-rehydrate and restore activity. Therefore, it has been widely used as a downstream process of biological products by vacuum freeze-drying. Vacuum freeze-drying equipment has also developed with the development of the bio-industry, with a high, precise and sharp development trend.
According to the internal report of Datamonitor, in 2014, vacuum freeze-drying equipment occupied the main market of drying equipment in the bio-industry, and the high-end vacuum freeze-drying equipment occupied the largest share of the vacuum freeze-drying equipment market, reaching about 70% of the whole industry.
The rapid development of the bio-industry has several major requirements for vacuum freeze-drying preservation:
1. Fully automated process;
2. Avoid cross-contamination;
3. Drying quickly and efficiently;
4. Personalized demand solution;
These requirements require vacuum freeze-drying equipment manufacturers to use high-precision machining processes, intelligent control technology, integrated refrigeration, vacuum new technology, to maximize the complex drying process. The world-renowned vacuum freeze-drying equipment manufacturers have invested a large amount of capital and manpower in the field of bio-industry applications for vacuum freeze-drying equipment, and have made various progress. European freeze dryer equipment manufacturers have proposed a perfect solution for wireless temperature measurement technology, which avoids cross-contamination to a certain extent and improves measurement accuracy. The fully automated freeze-drying line used by US freeze dryer manufacturers greatly optimizes the process route and improves the automated process of lyophilization. Bo Yikang proposed a total solution for the optimization of biotech drug freeze-drying process; in the bio-industry trial and pilot process, the eutectic point eutectic moisture rapid test function of the all-intelligent system greatly promoted the small test The experimental process of the pilot test.
With the development of vacuum freeze-drying equipment, fully automated and intelligent equipment will be more widely used in the bio-industry.
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